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Metabolic engineering

Metabolic and biosynthetic engineering of target pathways

2 3   engineer
ACIES BIO uses state-of-the-art microbiology and molecular biology methods (e.g. recombineering techniques), supported by systems biology principles (e.g. genome, transcriptome and proteome analysis), to engineer metabolic pathways and/or biosynthetic enzymes. These approaches can be used either in (a) strain improvement programs to increase the yield of a target product or reduce or eliminate the production of undesired impurities, as well as (b) in ‚Äúsynthetic biology‚ÄĚ projects to develop entirely new biosynthetic machineries. Such synthetic biology approaches can also be applied by ACIES to develop new metabolic pathways for sustainable production of high-value compounds/chemicals.

Although the particular objectives of such metabolic engineering projects may vary greatly between projects, typical development elements of such a project includes:

  • development / optimization of transformation procedures for the target strain
  • development / optimization of necessary genetic tools (vectors, promoters, etc.)
  • optimizing metabolic flux by up-regulation of a target pathway and/or knock-out of competing pathways
  • heterologous expression of foreign gene / gene cluster to introduce metabolites for biosynthesis of target product
  • mobilization and engineering of entire biosynthetic clusters and expression in native or heterologous production hosts




Within public call "Enhancing innovation potential and competences in companies", Acies Bio was recognised as one of the innovative companies with best potential to contribute to international competitiveness of Slovenia through smart specialisation.


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Acies was part of Bio World 2017, a unique forum for industry global leaders, policy makers and investors.  
The action is co-financed by the Republic of Slovenia and European Union from European Regional Development Fund.

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