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Metabolic engineering

Metabolic and biosynthetic engineering of target pathways

2 3   engineer
ACIES BIO uses state-of-the-art microbiology and molecular biology methods (e.g. recombineering techniques), supported by systems biology principles (e.g. genome, transcriptome and proteome analysis), to engineer metabolic pathways and/or biosynthetic enzymes. These approaches can be used either in (a) strain improvement programs to increase the yield of a target product or reduce or eliminate the production of undesired impurities, as well as (b) in “synthetic biology” projects to develop entirely new biosynthetic machineries. Such synthetic biology approaches can also be applied by ACIES to develop new metabolic pathways for sustainable production of high-value compounds/chemicals.

Although the particular objectives of such metabolic engineering projects may vary greatly between projects, typical development elements of such a project includes:

  • development / optimization of transformation procedures for the target strain
  • development / optimization of necessary genetic tools (vectors, promoters, etc.)
  • optimizing metabolic flux by up-regulation of a target pathway and/or knock-out of competing pathways
  • heterologous expression of foreign gene / gene cluster to introduce metabolites for biosynthesis of target product
  • mobilization and engineering of entire biosynthetic clusters and expression in native or heterologous production hosts




Within H2020 SME Innovation Associate project we invite a “Disease Model Development Manager” to join our team.




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ABCloneTM is fast and efficient solution for cloning of large natural and synthetic DNA fragments. We provide ABCloneTM as a stand alone service for getting quickly your long DNA fragment sub-cloned into plasmid vector of your choice.

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European Medicines Agency (EMA) granted orphan medicinal product designation to its lead compound CAB1803 for Pantothenate-kinase-associated neurodegeneration (PKAN)

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Scientists at ACIES BIO made a breakthrough innovation: high-value technology that uses unique and economic bioprocess to convert acid waste whey from dairy factories into high value animal feed products (vitamin B12) and clean water in the same process. Check out Whey2Value!



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Acies Bio received the “Jesenko Award” from Biotechnical Faculty of University of Ljubljana. The award recognizes institutions for their outstanding research work in the field of biotechnology.